Furthermore, even the recently discovered individual molecular markers of kidney injury (e.g., FGF-23, NGAL, IL-18, KIM-1, [TIMP-2].[IGFBP7]) detect AKI optimally at 12–24 h post-injury, when often irreversible damage is already present [4–7, 9]. The gene discussed is IGFBP7; the disease is acute kidney injury.