We identified four additional loci that had previously been associated with MD phenotypes or breast cancer risk and reached the Bonferroni-corrected thresholds accounting for the number of MD or breast cancer SNPs tested (P < 0.05/72 = 6.94 × 10−4 for MD, P < 0.05/195 = 2.56 × 10−4 for breast cancer risk) in Model 0: 5q23.2 (PRDM6), 8p21.2 (EBF2), 12p12.1 (SSPN), and 16q12.2 (FTO) (Table 3). The gene discussed is PRDM6; the disease is Menkes disease.