16q12.2 (Lead SNP: rs17817449, P = 1.12 × 10−6 for VSUM, Model 0) is a known locus for PD (P = 5.06 × 10−9) [8], overall (P = 2.52 × 10−21), ER + (P = 5.59 × 10−14), and ER − breast cancer risk (P = 1.80 × 10−10). The gene discussed is ESR1; the disease is breast carcinoma.