Positive correlations were also observed with overall (rg = 0.20, P = 6.90 × 10−3 for VSUM, Model 0) and ER + (rg = 0.22, P = 4.60 × 10−3 for VSUM, Model 0) breast cancer and became non-significant when adjusting for PD. The gene discussed is ESR1; the disease is breast cancer.