In conclusion, we performed a GWAS of breast parenchymal texture variation, V, and identified three independent loci at genome-wide significance, including 12q22 (PGAM1P5) that are associated with MD phenotypes and breast cancer risk and 6q24.1 (ECT2L) and 8q24.22 (LINC01591) that are novel V susceptibility loci. This evidence concerns the gene PGAM1P5 and Menkes disease.