Succinate accumulation in ccRC with decreased SDHD or SDHB expression was reported to enhance cancer cell invasion and metastasis by increasing DNA 5-methylcytosine (5mC) and suppressing 5-hydroxymethylcytosine (5-hmC) through inhibition of TET-2, resulting in global DNA hypermethylation [34]. The gene discussed is SDHD; the disease is cancer.