The first homozygous missense variant in FBXO32, c.727G > C: p.Gly243Arg, was discovered by Al-Yacoub et al. [10], who reported that the variant destroyed the SCF complex and dysregulated the autophagy/lysosomal system in early-onset DCM. Here, FBXO32 is linked to familial dilated cardiomyopathy.