A similarly duplicated gene found in Nile rat but not house mouse is Fndc4, where the second copy is almost full-length and validated by testis Iso-Seq data, with 97.8% identity and is located 1.3 Mb downstream of the canonical Fndc4. Fndc4 attenuates hyperlipidemia-induced insulin resistance in mice [85]. The gene discussed is FNDC4; the disease is Insulin resistance.