In the high-risk group, TP53 accounted for 42%, a remarkably higher value than that in the group with low risk, consistent with Calderaro’s research, wherein TP53-mutated HCC cells were poorly differentiated, densely packed, highly proliferative, multinucleated, and pleomorphic and exhibited frequent vascular infiltration [50]. The gene discussed is TP53; the disease is hepatocellular carcinoma.