LINC00680 and hepatocellular carcinoma: Recently, a research by Gege Shu et al. showed that LINC00680 is significantly over-expressed in HCC tissues, which boosts the stemness of HCC cells and reduces the chemical sensitivity to 5-fluorouracil (5-FU) in vitro and in vivo by sponging miR-568 implying that LINC00680 may be an essential diagnostic marker and therapeutic target for HCC [34].