Even though we were not able to show a significant effect in our smaller cohort A, a trend towards a differential distribution for both molecular markers IDH1 and 1p/19q between patients with and without seizures can be debated, especially with respect to the significant differences regarding the 1p/19q status in cohort B. Therefore, diffusion changes detected in seizure patients in this study should also be interpreted in the context of the underlying tumor biology. The gene discussed is IDH1; the disease is neoplasm.