It is noteworthy to mention that in a model of myocardial ischemia, Zhang Xl, et al. have shown the downregulation of TGFβRI along with the reduction of IL-6, TNF-α, and p-NFκB by miR-27a47; all of which are major inflammatory factors contributing to fibrosis pathogenesis. The gene discussed is TNF; the disease is myocardial ischemia.