SMAD4 and cervical adenocarcinoma: Consistent with our theory, Fang Fang, et al. have shown the ability of miR-27a to inhibit the TGF-β signaling pathway through suppression of TGF-βRI, Smad2, and Smad4 expression; as well as reduced phosphorylation of Smad3 in cervical adenocarcinoma; cell proliferation, migration, and invasion which employ the same mechanism of EMT in fibrosis, were also attenuated22.