We observed suggestive evidence of interactions between total folate intake and 3 independent gene sets on risk of CRC at FDR < 0.2, including Glutathione S-Transferase Alpha 1 (GSTA1; p = 4.3E−4), Tonsuko Like, DNA Repair Protein (TONSL; p = 4.3E−4), and Aspartylglucosaminidase (AGA; p = 4.5E−4). Here, GSTA1 is linked to colorectal carcinoma.