Both ΔS and ΔL showed the expected overexpression of Ifne and downstream type I IFN target genes (Extended Data Fig. 9i); nevertheless, these two genotypes showed differential response to acute Ifne: ΔS tumors had no response while ΔL tumors had a reduction in tumor size and metastasis (Fig. 8k,l). Here, IFNE is linked to neoplasm.