HP and cancer: Hp is an acidic highly sialylated glycoprotein with four N-glycosylation sites in its β-chain (Asn184, 207, 211, and 241) [6, 7], which has gained considerable attention due to its potential as a signature molecule that exhibits aberrant glycosylation in inflammatory disorders and various forms of malignant neoplasms (gastric, pancreatic, hepatic, prostate, lung, breast, ovarian, and colon) [2–4, 6, 8, 9].