Establishing the precise nature of SOX17 interactions with PTGIS and other genes involved in pathological processes in PAH such as PTGR248, SOD149, Wnt pathway modulator, DKK250,51 or lipid metabolism and insulin resistance regulator, KLF1652 is beyond the scope of this study and will require further investigation. This evidence concerns the gene PTGIS and pulmonary arterial hypertension.