Exposure of these BMPR2-deficient endothelial cells to hypoxia altered the expression of genes controlling oxygen transport, cell cycle, transcriptional regulation and inflammation, including genes with well-documented links to PAH: KCNK33,34, HDAC435, BRD412, CAMK2G36,37, and ICAM138. The gene discussed is BMPR2; the disease is pulmonary arterial hypertension.