Moreover, polymorphisms in maternal and fetal genes encoding excision repair cross-complementation group 1 (ERCC1), O-sialoglycoprotein endopeptidase, poly (ADP-ribose) polymerase 2 and ERCC5 were found to be associated with elevated risk of tobacco-associated CHD (Tang et al., 2015b). This evidence concerns the gene OSGEP and coronary artery disorder.