Genetic analyses revealed the roles of ligands and receptors in cell signaling pathways (JAG1, NOTCH1 and NOTCH2), transcription factors (GATA4, TBX5 and NKX2.5), laterality pathway-related proteins (NODAL, LEFTY and CITED2) and structural proteins (ACTC1, MYH6, MYH7 and MYH11) in CHD occurrence and development (Basu & Garg, 2018). The gene discussed is NOTCH1; the disease is coronary artery disorder.