Compared with normal cells, TRAF3IP2-AS1 was found to be expressed at low levels in response to the upregulation of the NONO-TFE3 fusion protein in NONO-TFE3 translocation renal cell carcinoma (tRCC). Here, TRAF3IP2 is linked to renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.