ABCB11 and cholangitis: Second, it controls the excretion and reabsorption of bile acids by regulating the target gene of bile salt export pump (BSEP, regulation of bile acid secretion) and sodium taurocholate transporter (NTCP, regulation of bile acid reabsorption), so as to maintain the stability of bile acid concentration15, avoid excessive accumulation of bile acids in the bile duct, lead to the occurrence of stones and cholangitis, cause repeated destruction and proliferation of bile duct cells, the emergence of heterogenous cells, and promote the further development of tumors.