Results indicated that patients with severe malaria had higher mean IFN-γ levels than those with uncomplicated malaria among studies that reported mean/standard deviation of IFN-γ levels (MD: 38.64 pg/mL, 95% CI 20.53–56.75 pg/mL, I2: 99.57%, five studies, 147 severe cases/211 uncomplicated cases). This evidence concerns the gene IFNG and malaria.