The subgroup analysis by the technique for IFN-γ measurement showed higher mean IFN-γ levels in patients with severe malaria than in those with uncomplicated malaria among studies using ELISA for IFN-γ measurement (MD: 26.79 pg/mL, 95% CI 15.26–38.31 pg/mL, I2: 99.05%, ten studies with 11 study sites). This evidence concerns the gene IFNG and malaria.