IFNG and malaria: The subgroup analysis by the study location (continent) showed higher mean IFN-γ levels in patients with severe malaria than in those with uncomplicated malaria among studies that were conducted in Asia (MD: 127.85 pg/mL, 95% CI 48.31–207.38 pg/mL, I2: 98.32%, four studies, 192 severe cases/251 uncomplicated cases).