IFNG and malaria: Meanwhile, no differences in mean IFN-γ levels between patients with severe and those with uncomplicated malaria were found among studies that reported median/range of IFN-γ levels (MD: 7.74 pg/mL, 95% CI − 1.24–16.71 pg/mL, I2: 97.93%, nine studies with ten study sites, 505 severe cases/885 uncomplicated cases, Supplementary Fig. S4).