IFNG and malaria: Results showed that patients with severe malaria had higher mean IFN-γ levels than those with uncomplicated malaria (p < 0.001, MD: 20.12 pg/mL, 95% CI 9.56–30.69 pg/mL, I2: 98.39%, 12 studies/13 study sites, 598 severe cases/1020 uncomplicated cases, Supplementary Fig. S3).