To further support the involvement of NgR2 in NEPrCa, we assessed the presence of NgR2 using immunohistochemical analysis (Fig. 2D) and scored the immunostaining intensity and percentage of cells at each staining level of 37 LuCaP PDXs43,51 in the tumor microarrays (TMAs) using the scoring system described in the Materials and Methods section and previously reported13. Here, RTN4RL2 is linked to neoplasm.