As far as we know, our study is the first to investigate the genotypic and allelic frequencies of the MUC7 VNTR variant among Egyptian children with bronchial asthma as well as to evaluate the associations between this variant and serum IgE, TNF-α, and TGF-β1 levels, and the clinical manifestation of the asthma disease. The gene discussed is TNF; the disease is asthma.