Significantly, mice deficient in Sirt1 develop sarcomas, lymphomas, teratomas, and carcinomas in a p53-deficient heterozygous background82,83, and Sirt1 overexpression in mice improves healthy aging84, protects from metabolic syndrome-associated cancer84, and suppresses age-dependent transcriptional changes82 that are attributed at least in part to its role in promoting genome integrity82–84. Here, SIRT1 is linked to metabolic syndrome.