For example, in addition to being significantly associated with asthma in the initial larger GWAS, variants near IL1RL1, KIAA2026, EMSY, and GSDMB were also associated with asthma in subgroup 3 “GI;” variants near TSLP, RANBP6, and SLC7A10 in subgroup 8 “Cardiovascular;” and variants near D2HGDH, HLA-DQA1, IL33, and SMAD3 in subgroups 3 and 8. The gene discussed is SMAD3; the disease is asthma.