The lead SNPs at the six subgroup-specific loci include rs11144271 (near OSTF1, p = 2.50 × 10−8) and rs113757163 (near COX10, p = 1.58 × 10−9) in subgroup 5 “Musculoskeletal,” rs2249851 (in FAM129B, p = 3.30 × 10−9) in subgroup 3 “GI,” rs76225731 (in SNHG14, p = 3.66 × 10−8) in subgroup 6 “Lung,” rs117262476 (in PCNT, p = 1.46 × 10−8) in subgroup 4 “Lymphoma,” and rs2765400 (near KRT8P37, p = 2.56 × 10−8) in subgroup 8 “Cardiovascular.” Five of the six subgroup-specific loci, except for the last one (rs2765400), were novel, meaning, never reported in any asthma GWASs before. This evidence concerns the gene COX10 and asthma.