CAMK2B and neoplasm: Second, the inferred kinase–substrate network highlighted a positive association between the abundance of CAMK2B protein (Ca2+/calmodulin-dependent protein kinase II beta) and its own phosphosite at Thr287 (Pearson’s R = 0.41; P = 0.02, Fig. 5e), indicating a potential role of CAMKII autophosphorylation, a commonly recognized Ca2+-independent activation manner to crosslink postsynaptic proteins30,31, in tumor development of Basal MTCs.