We showed that in osteosarcoma cells the expression of the mesenchymal markers N-cadherin and Vimentin and of MMP2 and MMP9 was all downregulated with SIRT2 knockdown, while the epithelial marker E-cadherin was decreased and N-cadherin, Vimentin, MMP2 and MMP9 were increased with SIRT2 overexpression. The gene discussed is SIRT2; the disease is osteosarcoma.