Accordingly, the LNC04168-knockdown-induced reduction in tumor growth was reversed by SHIP2 knockdown in a SNU-449 HCC model stably transfected with an shRNA for LNC04168 in vivo, suggesting that LNC04168 acts through SHIP2 downregulation to promote the growth of HCC tumors (Supplementary Fig. 2A and B). Here, INPPL1 is linked to hepatocellular carcinoma.