A luciferase-labeled AML cell line (HL60-luci+) was intravenously injected into B-NDG hIL15 mice (NOD.CB17-PrkdcscidIl2rgtm1Il15tm1(IL15)/Bcgen background) for the establishment of human AML tumor-bearing animals. Here, IL15 is linked to acute myeloid leukemia.