Between GAD and OCD, the differentially methylated genes we detected affected the development in different aspects: DMP gene SCRT1 regulated the conversion from microglia to neuron which was crucial for nerve system development [31, 32]; DMR gene SYCP1 regulated the fetal chromosome synapsis;[35, 36] DMP-DMR gene FAM172A was reported its DNA methylation was related to maternal circadian disruption which can affect the fetal development [39]. The gene discussed is SYCP1; the disease is generalized anxiety disorder.