PSMB4 and major depressive disorder: Among the top 10 DMP genes, we found two of them were related to mental health disorders: RIOK3 (cg21515243, Fig. 1F) was a gender-specific risk factor for Alzheimer’s disease [20] and PSMB4 (cg01334186, Fig. 1H) involved inflammation was related to the susceptibility to major depression [21].