MAPT and Dravet syndrome: Unexpectedly, we found significant trends of increased Aβ prions (R2 = 0.2752; P = 0.0042) and tau prions (R2 = 0.4328; P < 0.0001) in people with DS who lived longer (Fig. 3 A and B), which was consistent with the neuropathological and biochemical measurements of Aβ and tau proteins (SI Appendix, Fig. S2).