RYR2 and Bradycardia: Long-term SSYX treatment has been shown to restore calcium homeostasis and increase heart rate in the rabbit model of bradycardia by enhancing the expression of ryanodine receptor 2, sarcoplasmic/endoplasmic reticulum Ca2+ATPase 2 and voltage-dependent anion-selective channel.[88,89] From the analysis of the medicinal efficacy of each herb in prescription 2, its clinical effect was similar to that of the classical prescription “Zhigancao decoction” in Treatise on Cold Pathogenic and Miscellaneous Disease,[90] which has the effects of nourishing Yin and blood, warming Yang and replenishing Qi.