KLK3 and cancer: A combination of measurement of prostate-specific antigen (PSA) concentrations in blood with a prostate biopsy is known to be the standard diagnostic technique for PCa.[2] Standard biopsy is performed systemically, taking at least 8 cores according to the sextant prostate biopsy method.[3] The detection rate by biopsy is low as 25% of patients with PSA lab results show PSA values between 2 and 10 μg/L.[4,5] Although there is still no consensus on the adequate core number required for biopsy, it is well known that increasing the core number elevates the cancer detection rate.[3]