Following the development of the prostate imaging and reporting data system version 1 and 2 by the European Society of Urogenital Radiology,[16,17] mpMRI allows the clinician to determine prostate biopsy for patients with abnormal PSA and target the clinically important region within the prostate.[18,19] Interestingly, PSA and advanced age are known to be closely related to high grade PCa,[20] however, in the present study, PSA was not a significant factor, which may be a feature of BPH treated with dutasteride. Here, KLK3 is linked to benign prostatic hyperplasia.