PKM and central nervous system cancer: Glycolysis is a considerable marker of tumor cells and was found to be related to malignant progression in previous studies.[29,30] Malignant progression and glucose metabolism in glioma cells were promoted by Pyruvate kinase isoenzyme type M2 (PKM2),[31,32] while the expression of PKM2 in glioma cells was adjusted by the LINC00689/miR-338-3p axis.