As a kind of inflammasome sensors, NLRP1 mutations contributed to the activation of inflammasome in human skin.[32] Upregulated NLRP1 was associated with the increase of IFN-γ in ulcerative colitis and accelerated the progression of inflammatory bowel disease.[33] NLRP1 was also involved in the development of lung diseases. The gene discussed is NLRP1; the disease is inflammatory bowel disease.