A recent study revealed NLRP1 was a key sensor of SARS-CoV-2 infection in lung epithelia.[34] NLRP1 assembly enhanced release of caspase-1 and IL-1β and the activation of NLRP1 inflammasome promoted cell death and induced acute lung injury in mice.[35] Our study showed that serum NLRP1 was positively correlated with CRP, IL-6, IL-1β and TNF-α in COVID-19 patients. The gene discussed is TNF; the disease is COVID-19.