GPX4 and preeclampsia: Evidence suggests that ferroptosis may be involved in the pathophysiology of preeclampsia.[14] As a byproduct of lipid peroxidation and a hallmark of ferroptosis, elevated levels of MDA have been found in preeclamptic sera compared to normal pregnancy in several studies and MDA levels were positively correlated with the severity of the disease and negatively correlated with ferroptosis inhibitor concentrations.[15,16] Several investigations suggested that GPX4 (the loss of antioxidant production and turnover, a hallmark of ferroptosis) played a crucial role in preeclamptic pregnancies.