Some studies have demonstrated that NOX4 contributes to ferroptosis of astrocytes through oxidative stress-induced lipid peroxidation in Alzheimer’s disease.[47] NOX4 was upregulating through the activation of endoplasmic reticulum stress-induced activation of ATF3 thereby which led to produce hydrogen peroxide to promote ferroptosis in glioma cells.[48] Similarly, our study shows that NOX4 mRNA expression is identified as down regulated in STB-EVs derived from preeclampsia, which indicates the potential role of NOX4 as an Ferroptosis Driver in STB-EVs derived from preeclampsia. Here, ATF3 is linked to early-onset autosomal dominant Alzheimer disease.