GPX4 and preeclampsia: Several studies showed that two key genes involved in regulating intracellular iron transport are down regulated by exosomes: bivalent metal transporter 1[20] and iron regulatory protein 2.[21] Exosomes regulate the expression of GPX4 and FSP1,thereby inhibiting ferroptosis.[22,23] However, further improvements in preeclampsia therapeutic interventions that target ferroptosis demand a deep understanding of ferroptosis-related gene expression patterns in the STB-EVs.