NOX4 and Hypertension: ALB may cooperate with transferrin to limit the supply of iron, which may lead to preeclampsia.[43] Ferroptosis associated with ALB may act in hypertension through pathways such as retinol metabolism, branched-chain amino acid metabolism, drug metabolism-cytochrome P450 and biological processes.[44] PE showed elevated gene and protein expression of NOX4, one of the causes of cellular ROS.