The goal of this study was to include all prostate cancers diagnosed between 2005 and 2018 in the US and examine the association of race, Hispanic ethnicity, and stage with changes in prostate cancer incidence rates after the 2008 and 2012 USPSTF PSA screening guidelines, including the timing and duration of these changes.4,11 We hypothesized that patterns would differ among 5 race and ethnicity groups (African American, American Indian or Alaska Native, Asian or Pacific Islander, Hispanic, and White populations). This evidence concerns the gene KLK3 and prostate cancer.