KLK3 and Familial prostate cancer: Racial disparities in prostate cancer incidence have been found mostly between African American and White men in the US but not in American Indian or Alaska Native, Asian or Pacific Islander, or Hispanic individuals vs White individuals; this was also the case for decreasing prostate cancer incidence after PSA guideline changes.5,6,7,9 It is currently unknown if or how long the decrease would continue or the extent of the decrease, particularly in American Indian or Alaska Native, Asian or Pacific Islander, and Hispanic populations.