ADEM was categorized based on the presence of encephalopathy and acute imaging features only and therefore is unconfirmed based on the 2013 International Pediatric Multiple Sclerosis Society Group criteria.13 Myelin oligodendrocyte glycoprotein has been reported in pediatric patients with COVID-19,14 but we cannot determine in the 1 patient if it represents a primary or autoimmune response to SARS-CoV-2 or is unrelated. Here, OMG is linked to multiple sclerosis.