Urinary EGF and MCP1 levels have already been individually associated with increased risk of CKD progression in ADPKD patients [12–14], while the ratio of these two cytokines (uEGF/MCP1) has proven to be a useful prognostic biomarker in IgA nephropathy [15]. The gene discussed is EGF; the disease is autosomal dominant polycystic kidney disease.