Changes in the urinary epidermal growth factor and monocyte chemotactic peptide 1 were mirrored by gene expression levels in both human kidney cysts (epidermal growth factor: − 5.6-fold, fdr = 0.001; monocyte chemotactic peptide 1: 3.1-fold, fdr = 0.03) and Pkd1 knock-out mouse kidney (Egf: − 14.8-fold, fdr = 2.37E-20, Mcp1: 2.8-fold, fdr = 6.82E−15). Here, PKD1 is linked to Complex Cyst of Kidney.