Since MCT1 and MCT4 expression is increased in EAC compared to normal esophageal epithelium [14] and the effects of MCT1 blockade in esophageal adenocarcinoma have not been investigated yet, we conducted a study to analyze the expression of the lactate transporters MCT1 and MCT4 in human EAC biopsies and cell lines and evaluated whether pharmacological inhibition of the constitutive transporter MCT1 can exert antineoplastic effects on two different EAC cell lines. Here, SLC16A1 is linked to esophageal adenocarcinoma.