Hence, effective killing of such cancer cells will require two or more BH3-mimetic drugs, or combined treatment with one BH3-mimetic drug plus one or several standard-of-care anti-cancer agents that cause an increase in BH3-only proteins which then inhibit the pro-survival BCL-2 proteins that are not targeted by the BH3-mimetic drug used [20]. The gene discussed is BCL2; the disease is cancer.