However, analysis of single cell RNA-sequencing data from cohorts of colorectal, liver and lung cancer patients [18–21] showed that the percentages of TCF7 expressing CD8 + T cells are not increased in TILs compared to peripheral blood CD8 T cells (Fig. 1A), indicating that TCF7 is not induced specifically in the tumour microenvironment. Here, CD8A is linked to neoplasm.