However, analysis of Egr2high and Egr2low CD8 + TILs in GFP-Egr2 knockin mice revealed that Egr2high CD8 + TILs expressed much higher levels of checkpoint molecules than Egr2low CD8 + cells (Fig. 4C, D), consistent with the findings from Egr2high CD8 + TILs in human tumours [7]. This evidence concerns the gene CD8A and neoplasm.