Since global Ksr2 KO mice exhibited delayed fracture healing with an arrest at endochondral ossification, as observed in obese humans with T2D, and since KSR2 genetic polymorphisms are linked to obesity, an understanding of the cellular and molecular pathways of KSR2 regulation of mesenchymal stem cell fate may have important ramifications in promoting bone health in obese individuals. This evidence concerns the gene KSR2 and type 2 diabetes mellitus.