Furthermore, convergent RBD clones shared between IRF7LOF, TLR7LOF, IFNAR1LOF, APS-1, and HDs (Fig. 3 E) could be detected in all patients, in line with several studies showing that both natural infection with SARS-CoV-2 and SARS-CoV-2–specific mRNA vaccines elicited a highly convergent response in individuals (Cho et al., 2021; Robbiani et al., 2020). Here, AIRE is linked to infection.