IFNB1 and autoimmune polyendocrine syndrome type 1: The weak humoral response observed at early time points after mRNA vaccination in IFNAR1LOF patients, which contrasts with the initial normal response in APS-1 and IRF7LOF patients, could also reflect a role of IFN-β in driving the extrafollicular response, as previously hypothesized (Goldberg et al., 2021; Levin et al., 2021; Pegu et al., 2021; Thomas et al., 2021).