We thus performed an in-depth characterization of the anti–SARS-CoV-2 B cell response to BNT162b2 or mRNA-1273 mRNA vaccines in young and older patients with auto-Abs to type I IFNs due to APS-1 or age-associated autoimmunity, as well as in five patients with recessively inherited, complete IRF7, TLR7, or IFNAR1 deficiency, and compared these responses with young and adult healthy individuals up to 7 mo after mRNA vaccination. Here, TLR7 is linked to autoimmune polyendocrine syndrome type 1.