In systemic DLBCL, the 10 most frequently enriched genes included TP53 (348/969), MLL2 (302/969), IGH-BCL2 (256/969), CDKN2A (249/969), CDKN2B (165/969), CREBBP (164/969), BCL2 (159/969), TNFAIP3 (153/969), MYD88 (150/969), and TNFRSF14 (147/969) (Table 2). This evidence concerns the gene CREBBP and diffuse large B-cell lymphoma.