It has beensuggested that the combination of BIVA and BNP levels increases the ability todetect fluid overload in heart failure, improving treatment and prevent furthercomplications (Di Somma etal., 2010, 2014a; Santarelli, Russo, Lalle, De Berardinis, Navarin et al., 2017a),such as worsening renal function (Valle et al., 2011). This evidence concerns the gene NPPB and heart failure.