STAT3 and primary cutaneous T-cell non-Hodgkin lymphoma: To investigate the biological significance of the most commonly observed genetic aberrations for CTCL pathogenesis, namely STAT3/5, STAT1, SOCS1, TP53, and MYC, we correlated the detected CNA log2 ratios to the percentage of clonal CD3+ malignant cells detected in peripheral blood (Figs 2A–C and EV1B–E, and Table EV1).