For example, even though PD-1/TIM-3 double-positive CD8-positive TILs in ovarian cancer displayed enhanced potential for cytokine production and proliferation compared to other CD8-positive TIL subsets, patients highly expressing PD-1 and TIM-3 in TILs had reduced progression free survival compared to patients with low PD-1 and TIM-3 TIL expression. This evidence concerns the gene CD8A and ovarian cancer.