CXCL13/CD103/CD8 triple-positive TILs have previously been identified with B cell recruitment, TLS formation, neo-antigen burden and cytolytic gene signatures in human tumors and TIM-3 expression has been identified on CD39/CD103 double-positive tumor-reactive CD8-positive T cells (17, 25). The gene discussed is ENTPD1; the disease is neoplasm.