GJB3 and neoplasm: Consistently, the silencing of GJB3 dramatically suppressed the growth of tumor cell in the liver metastasis (Supplementary Figure 1) Further, we compared the overall survival time of shNC and shGJB3 group mice by Kaplan–Meier analysis and found that the median survival time of mice extend form 31 days to 41 days upon GJB3 silenced.