CD40LG and Huntington disease: In the corresponding local-HD group, significant upregulation of anti-viral antibody levels was noted against EBV (VCA IgG, VCA IgM, VCA IgA), HHV6A (IgM, IgA), and HERVK IgG, IgM, IgA (Figures 3A–C, H–L; Table S2B, S5) compared with negative-HD.