Within the cohort of HDs, a higher saliva RBD IgM/IgA-response was observed in local responders compared with systemic responders: local-HD vs systemic-HD: IgM: **p=0.0062, IgA: **p=0.0069; Figures 2B, C, Table S2B). The gene discussed is CD79A; the disease is Huntington disease.