Serum levels of high-sensitivity C-reactive protein (hsCRP), used as a biomarker for a cardiovascular event, are higher in young individuals with AP than in healthy controls, as well as IL-6, matrix metalloproteinase 8 (MMP-8), and soluble E-selectin, which are implicated in atherogenesis (29) (Figure 1). The gene discussed is MMP8; the disease is alkaline phosphatase measurement.