We observed that the AA1 phenotype could be described as a COAD subtype predominantly originating from the right colon and was associated with a higher MutL Homolog 1 (MLH1) silent mutation rate, a higher proportion of microsatellite instability (MSI) status, and a CpG island methylator phenotype (CIMP) subtype compared to the AA2 subtype (Figures 1F–I). This evidence concerns the gene MLH1 and colon adenocarcinoma.