Similarly, significant donor engraftment was seen following HSCT in a mouse model of Fanconi anemia (FA) that has an inherent HSC defect; CD4 depletion and c-kit mAb further improved multilineage donor engraftment in this minor histocompatibility antigen mismatch transplant model as compared to c-kit mAb (50). This evidence concerns the gene KIT and Fanconi anemia.