Complement C8 is a main component of the membrane attack complex, and high expression of one of its subunits, C8B, is correlated with better overall survival and recurrence-free survival in HBV-related HCC patients (39), suggesting that the expression of C8B could serve as a good prognostic indicator in this group of HCC patients. The gene discussed is C8B; the disease is hepatocellular carcinoma.