CXCL12 and neoplasm: The CCR2 inflammatory monocytes are recruited in the tumor by CCL2 (17), and the macrophages are attracted by cancer-associated fybroblasts (CAFs) through SDF-1/CXCL12 expression, indeed SDF-1 magnifies the polarization of the macrophages into tumor- associated macrophages (TAMs) (producing high levels of IL-10).